Th-POK (full length) antibody

Catalog No. ABIN7879140

The Mouse Monoclonal anti-Th-POK antibody is suitable to detect Th-POK in samples from Human. It has been validated for FACS, IF and WB.

Quick Overview for Th-POK (full length) antibody (ABIN7879140)

Target: Th-POK

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)

Clone: PCRP-ZBTB7B-1B6

Product Details

Binding Specificity: full length

Purpose: Th-Pok Antibody / ZBTB7B

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human Zinc finger and BTB domain-containing protein 7B protein was used as the immunogen for the Th-Pok antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Th-Pok antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Th-Pok antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details

Target: Th-POK

Background: TH-POK (T-helper-inducing POZ/Kr ppel-like factor), also known as zinc finger protein 67 (ZFP67), zinc finger and BTB domain-containing protein 7B or Kr ppel-related zinc finger protein cKrox, is a 539 amino acid protein that contains one BTB (POZ) domain and four C2H2-type zinc fingers. Localized to the nucleus, TH-POK functions primarily as a key regulator of lineage commitment of immature T-cell precursors. Specifically, the presence of TH-POK directs positively selected thymocytes to the CD4 lineage, whereas its absence causes default development to the CD8 lineage. TH-POK also functions as a transcriptional repressor of various other genes, such as COL1A1, COL1A2 and Fibronectin.

UniProt: O15156