Recombinant Topoisomerase I antibody (full length)

Catalog No. ABIN7879153

The Mouse Monoclonal anti-Topoisomerase I antibody (Clone rTOP1MT-488) (ABIN7879153) specifically detects Topoisomerase I in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Topoisomerase I antibody (full length) (ABIN7879153)

Target: Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Topoisomerase I antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RTOP1MT-488

Product Details anti-Topoisomerase I Antibody

Binding Specificity: full length

Purpose: Recombinant DNA topoisomerase I Antibody / TOP1MT (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human TOP1MT protein was used as the immunogen for the recombinant DNA topoisomerase I antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant DNA topoisomerase I antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant DNA topoisomerase I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Topoisomerase I

Target: Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

Alternative Name: DNA topoisomerase I

Background: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

UniProt: Q969P6

Pathways: Caspase Cascade in Apoptosis, Stem Cell Maintenance