Recombinant Transgelin antibody (full length)

Catalog No. ABIN7879182

The Mouse Monoclonal anti-Transgelin antibody is suitable to detect Transgelin in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant Transgelin antibody (full length) (ABIN7879182)

Target: Transgelin (TAGLN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transgelin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RTAGLN-8975

Product Details anti-Transgelin Antibody

Binding Specificity: full length

Purpose: Recombinant Transgelin Antibody / SM22 alpha

Sequence: TAGLN

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human Transgelin (TAGLN) protein was used as the immunogen for the recombinant Transgelin antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Transgelin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Transgelin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Transgelin

Target: Transgelin (TAGLN)

Alternative Name: Transgelin

Background: This mAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.

UniProt: Q01995