Tropomyosin antibody (full length)

Catalog No. ABIN7879210

The Mouse Monoclonal anti-Tropomyosin antibody (Clone TPM1-4510) (ABIN7879210) specifically detects Tropomyosin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Tropomyosin antibody (full length) (ABIN7879210)

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tropomyosin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPM1-4510

Product Details anti-Tropomyosin Antibody

Binding Specificity: full length

Purpose: Alpha Tropomyosin Antibody / Tropomyosin-1 / TPM1

Purification: Protein A/G affinity

Immunogen: Recombinant full-length protein was used as the immunogen for the Alpha Tropomyosin antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the Alpha Tropomyosin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Alpha Tropomyosin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Tropomyosin

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Alternative Name: Alpha Tropomyosin

Background: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin Alpha is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.

UniProt: P04268

Pathways: Regulation of Actin Filament Polymerization