TYR antibody (full length)

Catalog No. ABIN7879270

The Mouse Monoclonal anti-TYR antibody (Clone TYR-3826) (ABIN7879270) specifically detects TYR in IHC (p). The antibody is reactive with Human samples.

Quick Overview for TYR antibody (full length) (ABIN7879270)

Target: TYR (Tyrosinase (TYR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TYR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TYR-3826

Product Details anti-TYR Antibody

Binding Specificity: full length

Purpose: Tyrosinase Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human Tyrosinase protein was used as the immunogen for the Tyrosinase antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Tyrosinase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Tyrosinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TYR

Target: TYR (Tyrosinase (TYR))

Alternative Name: Tyrosinase

Background: Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants.This MAb is a useful marker for melanocytes and melanomas.

UniProt: P14679