UBE2C antibody (full length)

Catalog No. ABIN7879294

The Mouse Monoclonal anti-UBE2C antibody (Clone CPTC-UBE2C-1) (ABIN7879294) specifically detects UBE2C in ELISA and IHC (p). The antibody is reactive with Human samples.

Quick Overview for UBE2C antibody (full length) (ABIN7879294)

Target: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This UBE2C antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CPTC-UBE2C-1

Product Details anti-UBE2C Antibody

Binding Specificity: full length

Purpose: UBE2C Antibody / UBCH10

Purification: Protein G affinity chromatography

Immunogen: Recombinant human full-length protein was used as the immunogen for the UBE2C antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the UBE2C antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the UBE2C antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for UBE2C

Target: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Alternative Name: UBE2C

Background: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ubconjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an E2 ubiquitin conjugating enzyme for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.

UniProt: O00762

Pathways: Ubiquitin Proteasome Pathway