Recombinant TFF1 antibody (C-Term, full length)

Catalog No. ABIN7879390

The Mouse Monoclonal anti-TFF1 antibody (Clone rTFF1-1091) (ABIN7879390) specifically detects TFF1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant TFF1 antibody (C-Term, full length) (ABIN7879390)

Target: TFF1 (Trefoil Factor 1 (TFF1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TFF1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RTFF1-1091

Product Details anti-TFF1 Antibody

Binding Specificity: C-Term, full length

Purpose: Recombinant pS2 Antibody / TFF1

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human protein was used as the immunogen for this recombinant pS2 antibody. Its epitope is located in the c-terminal region of human pS2 protein.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant pS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant pS2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Alternative Name: pS2

Background: It recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60 % of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

UniProt: P04155

Pathways: EGFR Signaling Pathway