HDAC1 antibody (Middle Region)

Catalog No. ABIN7879524

The Rabbit Polyclonal anti-HDAC1 antibody is suitable to detect HDAC1 in samples from Zebrafish (Danio rerio). It has been validated for IHC (p).

Quick Overview for HDAC1 antibody (Middle Region) (ABIN7879524)

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HDAC1 Antibody

Binding Specificity: Middle Region

Purpose: Zebrafish Hdac1 Antibody / Histone deacetylase 1

Purification: Antigen affinity chromatography

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of zebrafish Hdac1 was used as the immunogen for the Zebrafish Hdac1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Hdac1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Hdac1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HDAC1

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Alternative Name: Hdac1

Background: Histone deacetylase 1 is an enzyme that is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multi-subunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. Furukawa et al.(1996) mapped RPD3L1 to 1p34.1 by fluorescence in situ hybridization.

Pathways: Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis