CGA antibody (N-Term)

Catalog No. ABIN7879606

The Rabbit Polyclonal anti-CGA antibody (ABIN7879606) specifically detects CGA in WB, IHC and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CGA antibody (N-Term) (ABIN7879606)

Target: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CGA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-CGA Antibody

Binding Specificity: N-Term

Purpose: CGA Antibody / Choriogonadotropin alpha

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Choriogonadotropin alpha was used as the immunogen for the CGA antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CGA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CGA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CGA

Target: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Alternative Name: CGA

Background: CGA antibody detects Choriogonadotropin alpha, a glycoprotein hormone subunit that forms the alpha component of several pituitary and placental hormones. The UniProt recommended name is Glycoprotein hormones alpha chain (CGA). This protein combines with distinct beta subunits to create functional heterodimeric hormones, including luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). These hormones regulate key reproductive and endocrine processes such as ovulation, pregnancy maintenance, and thyroid function.

Functionally, CGA antibody identifies a 92-amino-acid secreted glycoprotein synthesized in the anterior pituitary gland and placenta. The alpha subunit provides a conserved structural framework that enables pairing with hormone-specific beta subunits, which determine receptor specificity and biological activity. CGA is heavily glycosylated, and its carbohydrate chains are essential for stability, secretion, and receptor binding. It plays a crucial role in endocrine signaling, coordinating hormonal responses across reproductive and metabolic systems.

The CGA gene is located on chromosome 6q12-q21 and is expressed in trophoblastic tissue, pituitary gonadotrophs, and thyrotrophs. In the placenta, it combines with the hCG beta subunit to form human chorionic gonadotropin, a hormone vital for sustaining early pregnancy by maintaining progesterone production. CGA expression is hormonally regulated and responsive to gonadotropin-releasing hormone (GnRH), thyroid-stimulating hormone-releasing factor, and estrogen signaling.

Clinically, altered CGA levels or misfolding can affect reproductive function and thyroid regulation. Elevated circulating hCG, which includes the CGA subunit, is a diagnostic marker for pregnancy and certain trophoblastic or germ cell tumors. Overexpression of free alpha subunit is also observed in some pituitary adenomas and endocrine malignancies. Research using CGA antibody supports studies in reproductive biology, placental development, and hormonal regulation.

CGA antibody is validated for use in relevant research applications to detect the alpha subunit of glycoprotein hormones and study its role in endocrine signaling. NSJ Bioreagents provides CGA antibody reagents optimized for reproductive, endocrine, and diagnostic hormone research.

UniProt: P01215

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport, Peptide Hormone Metabolism