GNRHR antibody (N-Term)

Catalog No. ABIN7879608

The Mouse Monoclonal anti-GNRHR antibody is suitable to detect GNRHR in samples from Human. It has been validated for ELISA.

Quick Overview for GNRHR antibody (N-Term) (ABIN7879608)

Target: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GNRHR antibody is un-conjugated

Application: ELISA

Clone: A9E4

Product Details anti-GNRHR Antibody

Binding Specificity: N-Term

Purpose: GnRH-Receptor Antibody / LHCG Receptor

Sequence: MANSASPEQN QHCSAINNSI PLMQGNLPY

Purification: Protein A/G affinity

Immunogen: amino acids MANSASPEQNQHCSAINNSIPLMQGNLPY from the N-terminal of human GnRH receptor was used as the immunogen for the GnRH-Receptor antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the GnRH-Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GnRH-Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GNRHR

Target: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Alternative Name: GnRH-Receptor

Background: Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.

UniProt: P30968