MS4A6E antibody (N-Term)

Catalog No. ABIN7879621

The Rabbit Polyclonal anti-MS4A6E antibody (ABIN7879621) specifically detects MS4A6E in WB. The antibody is reactive with Human samples.

Quick Overview for MS4A6E antibody (N-Term) (ABIN7879621)

Target: MS4A6E (Membrane-Spanning 4-Domains, Subfamily A, Member 6E (MS4A6E))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MS4A6E antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MS4A6E Antibody

Binding Specificity: N-Term

Purpose: MS4A6E Antibody / Membrane spanning 4-domains subfamily A member 6E

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human MS4A6E was used as the immunogen for the MS4A6E antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MS4A6E antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MS4A6E antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MS4A6E

Target: MS4A6E (Membrane-Spanning 4-Domains, Subfamily A, Member 6E (MS4A6E))

Alternative Name: MS4A6E

Background: MS4A6E antibody detects Membrane spanning 4-domains subfamily A member 6E, encoded by the MS4A6E gene. MS4A6E is part of the MS4A protein family, which includes CD20, MS4A4A, and other membrane proteins involved in immune signaling and cellular communication. MS4A6E antibody provides researchers with a tool to study membrane biology, immune function, and disease processes associated with the MS4A family.

Membrane spanning 4-domains subfamily A member 6E is a predicted transmembrane protein with four membrane-spanning segments, but its precise cellular role remains under investigation. Research using MS4A6E antibody has suggested that it localizes to the plasma membrane and endosomal compartments. Like other MS4A family proteins, it may participate in signal transduction, calcium flux, or membrane organization.

Studies with MS4A6E antibody have demonstrated expression in immune-related tissues and the central nervous system. Genome-wide association studies have linked variants in MS4A6E to Alzheimer disease risk, suggesting functional involvement in neuroinflammation and amyloid processing. These findings highlight MS4A6E as a potential modulator of neurodegeneration through immune and signaling pathways.

In addition to neurological disease, MS4A6E expression changes have been observed in cancers. Research using MS4A6E antibody has shown that altered expression correlates with tumor progression and immune evasion. This suggests that MS4A6E may influence the tumor microenvironment and serve as a biomarker for certain malignancies.

MS4A6E antibody is commonly applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects protein expression in brain and immune tissues, immunohistochemistry localizes expression in tissue sections, and immunofluorescence reveals subcellular distribution. These approaches make MS4A6E antibody valuable for research into both immune and neurological biology.

By providing validated MS4A6E antibody reagents, NSJ Bioreagents supports studies into membrane proteins, neurodegeneration, and immune regulation. Detection of Membrane spanning 4-domains subfamily A member 6E provides researchers with insight into how MS4A proteins contribute to health and disease.

UniProt: Q96DS6