Neurexin 2 (NRXN2) (N-Term) antibody

Catalog No. ABIN7879631

This Rabbit Polyclonal antibody specifically detects Neurexin 2 in WB. It exhibits reactivity toward Rat and Mouse.

Quick Overview for Neurexin 2 (NRXN2) (N-Term) antibody (ABIN7879631)

Target: Neurexin 2 (NRXN2)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Binding Specificity: N-Term

Purpose: NRXN2 Antibody / Neurexin 2

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human NRXN2 was used as the immunogen for the NRXN2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NRXN2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NRXN2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details

Target: Neurexin 2 (NRXN2)

Alternative Name: NRXN2

Background: NRXN2 antibody detects Neurexin 2, a presynaptic cell adhesion molecule that plays a key role in synapse formation, neuronal communication, and neurotransmitter release. Encoded by the NRXN2 gene on chromosome 11q13.1, this protein belongs to the neurexin family of cell surface receptors that mediate trans-synaptic signaling by binding postsynaptic partners such as neuroligins and LRRTMs. Neurexin 2 is expressed primarily in the brain and spinal cord, where it contributes to the assembly and maintenance of excitatory and inhibitory synapses.

Structurally, Neurexin 2 exists in multiple isoforms generated by alternative promoter usage and extensive splicing, including a long alpha form and a shorter beta form. The alpha isoform contains laminin, neurexin, and sex hormone-binding globulin (LNS) domains as well as EGF-like repeats that facilitate adhesion and receptor interaction. The beta isoform retains the transmembrane and cytoplasmic PDZ-binding motifs that mediate synaptic signaling. These isoforms together ensure molecular diversity and specificity in synapse targeting and stability.

The NRXN2 antibody is widely used in neuroscience, neurodevelopmental, and molecular signaling research to study synaptic connectivity, axon guidance, and neuropsychiatric disorders. Western blot analysis detects multiple bands corresponding to the various isoforms of Neurexin 2 (ranging from 95 to 160 kilodaltons), while immunofluorescence shows punctate staining along axons and presynaptic terminals. This antibody enables characterization of neurexin distribution and expression in both developing and mature neural networks.

Functionally, Neurexin 2 regulates synapse formation by bridging pre- and postsynaptic membranes, facilitating calcium channel clustering and neurotransmitter release. Mutations or deletions in NRXN2 have been associated with autism spectrum disorder, schizophrenia, and intellectual disability, reflecting its critical role in neuronal circuit function. The NRXN2 antibody provides an essential tool for examining how neurexin-mediated adhesion and signaling shape neuronal connectivity and plasticity. NSJ Bioreagents validates this antibody for its applications, ensuring accurate detection for neurobiological research.

UniProt: P58401

Pathways: Synaptic Membrane