Neurogenin 1 antibody (N-Term)

Catalog No. ABIN7879632

The Rabbit Polyclonal anti-Neurogenin 1 antibody is suitable to detect Neurogenin 1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC (p).

Quick Overview for Neurogenin 1 antibody (N-Term) (ABIN7879632)

Target: Neurogenin 1 (NEUROG1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurogenin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Neurogenin 1 Antibody

Binding Specificity: N-Term

Purpose: Neurogenin 1 Antibody / NEUROG1

Purification: Antigen affinity purified

Immunogen: An amino acid sequence from the N-terminal region of the human protein was used as the immunogen for the Neurogenin 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Neurogenin 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Neurogenin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Neurogenin 1

Target: Neurogenin 1 (NEUROG1)

Alternative Name: Neurogenin 1

Background: NEUROG1 (Neurogenin 1) is a basic helix-loop-helix (bHLH) transcription factor that plays a key role in neurogenesis. It functions as a proneural gene, promoting the differentiation of neural progenitor cells into neurons by activating downstream transcriptional programs. NEUROG1 is expressed during early development in regions of the central and peripheral nervous systems where it contributes to neuronal specification and lineage determination. A NEUROG1 antibody is widely used to study developmental neurobiology and transcriptional regulation in neural tissues.

As a member of the neurogenin family, NEUROG1 influences the balance between proliferation and differentiation of progenitor cells. It activates pro-neural genes while repressing alternate cell fates, thereby guiding stem cells toward a neuronal identity. In addition, NEUROG1 interacts with other transcription factors and signaling pathways, including Notch signaling, to ensure precise control of neuronal patterning. Using a NEUROG1 antibody allows researchers to monitor expression patterns and regulatory interactions in neural tissue and stem cell models.

Dysregulation of NEUROG1 has been associated with impaired neural development and has implications for neurodevelopmental disorders. Its expression is also studied in cancer biology, particularly in tumors of neural origin, where abnormal transcription factor activity may contribute to tumorigenesis. Employing a NEUROG1 antibody provides a reliable tool to study its role in both normal development and disease-related contexts.

NSJ Bioreagents provides a high-quality NEUROG1 antibody validated for applications such as immunohistochemistry, western blot, and immunofluorescence. Choosing a NEUROG1 antibody from NSJ Bioreagents ensures consistent results and reproducibility in studies of neuronal differentiation and transcriptional regulation.

UniProt: Q92886