Sialoadhesin/CD169 antibody (N-Term)

Catalog No. ABIN7879652

This Mouse Monoclonal antibody specifically detects Sialoadhesin/CD169 in FACS, WB, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Sialoadhesin/CD169 antibody (N-Term) (ABIN7879652)

Target: Sialoadhesin/CD169 (SIGLEC1) (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Sialoadhesin/CD169 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: HSn 7D2

Product Details anti-Sialoadhesin/CD169 Antibody

Binding Specificity: N-Term

Purpose: SIGLEC1 Antibody / CD169 / Sialoadhesin (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: An Fc fusion protein containing N-terminal 4 domains of human sialoadhesin was used as the immunogen for this SIGLEC1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the SIGLEC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the SIGLEC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Sialoadhesin/CD169

Target: Sialoadhesin/CD169 (SIGLEC1) (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))

Alternative Name: SIGLEC1

Background: Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1,709 amino acid protein, also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant, encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells.