CTNND1 antibody (pTyr96)

Catalog No. ABIN7879841

This Mouse Monoclonal antibody specifically detects CTNND1 in IF and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CTNND1 antibody (pTyr96) (ABIN7879841)

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTNND1 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: 25a

Product Details anti-CTNND1 Antibody

Binding Specificity: pTyr96

Purpose: p120 Catenin Antibody (pTyr96) / CTNND1 / Catenin delta 1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: The amino acid sequence surrounding phosphorylated Tyr96 was used as the immunogen for the p120 Catenin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the p120 Catenin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the p120 Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CTNND1

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Alternative Name: p120 Catenin

Background: The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.

UniProt: O60716

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling