Acetyl-CoA Carboxylase alpha antibody

Catalog No. ABIN7879859

This Rabbit Polyclonal antibody specifically detects Acetyl-CoA Carboxylase alpha in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Acetyl-CoA Carboxylase alpha antibody (ABIN7879859)

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetyl-CoA Carboxylase alpha antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Acetyl-CoA Carboxylase alpha Antibody

Purpose: ACACA Antibody / ACC / Acetyl CoA Carboxylase 1

Sequence: DSIIHMTQHI SPTQRAEVIR

Purification: Antigen affinity purified

Immunogen: Amino acids DSIIHMTQHISPTQRAEVIR were used as the immunogen for the ACACA antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ACACA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ACACA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Acetyl-CoA Carboxylase alpha

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Alternative Name: ACACA

Background: Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect