ALDH1L1 antibody

Catalog No. ABIN7879938

The Mouse Monoclonal anti-ALDH1L1 antibody is suitable to detect ALDH1L1 in samples from Human. It has been validated for IHC (p).

Quick Overview for ALDH1L1 antibody (ABIN7879938)

Target: ALDH1L1 (Aldehyde Dehydrogenase 1 Family, Member L1 (ALDH1L1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ALDH1L1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ALDH1L1-7958

Product Details anti-ALDH1L1 Antibody

Purpose: ALDH1L1 Antibody

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human ALDH1L1 protein was used as the immunogen for the ALDH1L1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the ALDH1L1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ALDH1L1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ALDH1L1

Target: ALDH1L1 (Aldehyde Dehydrogenase 1 Family, Member L1 (ALDH1L1))

Alternative Name: ALDH1L1

Background: Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1L1 (aldehyde dehydrogenase 1 family member L1), also known as FTHFD or 10-FTHFD (10-formyltetrahydrofolate dehydrogenase), is a cytosolic protein that is developmentally regulated in the cerebellum. ALDH1L1 binds to folate and catalyzes the conversion of 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF). This suggests a possible role for ALDH1L1 in the regulation of cellular THF levels as well as in the inhibition of cell proliferation (as 10-FTHF is essential for the synthesis of purine). In addition, the overexpression of ALDH1L1 can restrict cell proliferation in vitro.

UniProt: O75891