Alkaline Phosphatase antibody

Catalog No. ABIN7879949

This Mouse Monoclonal antibody specifically detects Alkaline Phosphatase in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Alkaline Phosphatase antibody (ABIN7879949)

Target: Alkaline Phosphatase (ALP)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Alkaline Phosphatase antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: SPM372

Product Details anti-Alkaline Phosphatase Antibody

Purpose: Alkaline Phosphatase Antibody / ALPL (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Bovine intestinal alkaline phosphatase was used as the immunogen for the Alkaline Phosphatase antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Alkaline Phosphatase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Alkaline Phosphatase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Alkaline Phosphatase

Target: Alkaline Phosphatase (ALP)

Alternative Name: Alkaline Phosphatase

Background: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

UniProt: P09923