Fetuin A antibody

Catalog No. ABIN7879956

The Mouse Monoclonal anti-Fetuin A antibody is suitable to detect Fetuin A in samples from Human. It has been validated for IHC (p).

Quick Overview for Fetuin A antibody (ABIN7879956)

Target: Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fetuin A antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AHSG-3748

Product Details anti-Fetuin A Antibody

Purpose: Fetuin-A Antibody / AHSG

Purification: Protein A/G affinity

Immunogen: A recombinant protein fragment was used as the immunogen for the Fetuin-A antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Fetuin-A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Fetuin-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Fetuin A

Target: Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))

Alternative Name: Fetuin-A

Background: Fetuin (also designated 2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.

UniProt: P02765