alpha 2 Macroglobulin antibody

Catalog No. ABIN7879957

The Rabbit Monoclonal anti-alpha 2 Macroglobulin antibody (Clone ABAO-1) (ABIN7879957) specifically detects alpha 2 Macroglobulin in WB. The antibody is reactive with Human samples.

Quick Overview for alpha 2 Macroglobulin antibody (ABIN7879957)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This alpha 2 Macroglobulin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABAO-1

Product Details anti-alpha 2 Macroglobulin Antibody

Purpose: Alpha-2-macroglobulin Antibody / A2M

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human A2M / Alpha 2 Macroglobulin was used as the immunogen for the Alpha-2-macroglobulin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Alpha-2-macroglobulin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Alpha-2-macroglobulin antibody at -20oC.

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: Alpha-2-macroglobulin

Background: Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [RefSeq]

UniProt: P01023

Pathways: Lipid Metabolism