Recombinant Annexin VII antibody

Catalog No. ABIN7879981

The Rabbit Monoclonal anti-Annexin VII antibody (Clone 30A75) (ABIN7879981) specifically detects Annexin VII in WB, IHC and IP. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant Annexin VII antibody (ABIN7879981)

Target: Annexin VII (ANXA7) (Annexin A7 (ANXA7))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Annexin VII antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 30A75

Product Details anti-Annexin VII Antibody

Purpose: Annexin A7 Antibody / ANXA7

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Annexin A7 was used as the immunogen for the Annexin A7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Annexin A7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Annexin A7 antibody at -20oC.

Target Details for Annexin VII

Target: Annexin VII (ANXA7) (Annexin A7 (ANXA7))

Alternative Name: Annexin A7

Background: Annexin A7 antibody detects annexin A7, a calcium and phospholipid binding protein encoded by the ANXA7 gene. Annexin A7 belongs to the annexin protein family, which share conserved annexin repeat domains that mediate calcium dependent membrane interactions. This protein participates in exocytosis, membrane fusion, and calcium signaling, making it a key regulator of vesicular transport and cellular communication across multiple tissues.

Annexin A7 antibody is widely applied in neuroscience, cardiovascular biology, and oncology. In the nervous system, annexin A7 contributes to synaptic vesicle release and neurotransmitter secretion. In cardiac muscle, it supports calcium handling and myocardial contractility. Dysregulation of annexin A7 has been associated with several cancers, where it influences tumor growth, cell motility, and drug resistance. By detecting annexin A7, researchers can study its role in both normal physiology and disease mechanisms.

In western blot assays, annexin A7 antibody identifies protein bands of the expected molecular weight in tissue lysates. Immunohistochemistry maps annexin A7 expression in brain, heart, and epithelial tissues, while immunofluorescence highlights cytoplasmic and membrane localization. These applications enable detailed analysis of annexin A7 in cellular signaling and trafficking.

Annexin A7 is involved in calcium dependent regulation of phospholipase activity and contributes to processes including apoptosis, proliferation, and membrane repair. Altered expression has been linked to cancer biology, cardiovascular disorders, and neurological diseases. In oncology, annexin A7 has been studied as both a tumor suppressor and promoter, depending on cellular context. By applying annexin A7 antibody, scientists can investigate how annexin mediated pathways affect tumor progression and therapy response.

Beyond cancer and cardiovascular research, annexin A7 also plays roles in endocrine function, fertility, and immune signaling. Its presence in secretory cells suggests contributions to hormone release and immune mediator secretion. These diverse functions emphasize the importance of annexin A7 as a research target across multiple biological systems.

Annexin A7 antibody from NSJ Bioreagents delivers reliable specificity for detecting this multifunctional calcium binding protein. Its strong performance across techniques ensures accurate results, supporting basic research as well as translational studies in neuroscience, cardiology, and oncology.

UniProt: P20073