Recombinant Centaurin beta 2 antibody

Catalog No. ABIN7879997

This Rabbit Monoclonal antibody specifically detects Centaurin beta 2 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant Centaurin beta 2 antibody (ABIN7879997)

Target: Centaurin beta 2 (ACAP2) (ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Centaurin beta 2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 30A18

Product Details anti-Centaurin beta 2 Antibody

Purpose: ACAP2 Antibody / ArfGAP with coiled-coil ankyrin repeat and PH domains 2

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human ACAP2 was used as the immunogen for the ACAP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ACAP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the ACAP2 antibody at -20oC.

Target Details for Centaurin beta 2

Target: Centaurin beta 2 (ACAP2) (ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 2 (ACAP2))

Alternative Name: ACAP2

Background: ACAP2 antibody detects ArfGAP with coiled-coil, ankyrin repeat, and PH domains 2, a GTPase-activating protein that regulates ADP-ribosylation factor 6 (ARF6). ACAP2 controls membrane trafficking and actin cytoskeleton remodeling by accelerating the hydrolysis of ARF6-bound GTP. Through these functions, ACAP2 coordinates processes such as endocytosis, recycling, and cell migration.

Research using ACAP2 antibody demonstrates its role in neuronal and immune cell biology. In neurons, ACAP2 regulates dendritic spine development and axon guidance by modulating actin remodeling. In immune cells, ACAP2 contributes to receptor trafficking and migration, influencing both innate and adaptive responses. Dysregulation of ACAP2 has been associated with impaired immune function and altered neuronal connectivity.

ACAP2 is also studied in cancer and viral infections. Tumor cells exploit ARF6 signaling pathways to promote invasion and metastasis, and ACAP2 acts as a regulator of this activity. Reduced ACAP2 expression can enhance ARF6-mediated oncogenic signaling. Viral pathogens, including some RNA viruses, utilize ARF6 and its regulators to facilitate replication and budding, suggesting ACAP2 may indirectly impact host-pathogen interactions.

Antibodies against ACAP2 are validated for western blot, immunofluorescence, and immunohistochemistry. These reagents allow researchers to investigate protein localization, expression levels, and interactions with ARF6 and related molecules. Clone-based antibodies provide specificity to ensure consistent results across experimental systems.

NSJ Bioreagents supplies this ACAP2 antibody for studies in membrane trafficking, cytoskeletal regulation, and signaling pathways.

UniProt: Q15057