BUB1B antibody

Catalog No. ABIN7880116

The Rabbit Monoclonal anti-BUB1B antibody (Clone ABFG-2) (ABIN7880116) specifically detects BUB1B in WB. The antibody is reactive with Human samples.

Quick Overview for BUB1B antibody (ABIN7880116)

Target: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BUB1B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABFG-2

Product Details anti-BUB1B Antibody

Purpose: BUB1B Antibody

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human BUB1B was used as the immunogen for the BUB1B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the BUB1B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the BUB1B antibody at -20oC.

Target Details for BUB1B

Target: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Alternative Name: BUB1B

Background: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta,' also called BubR1, is an essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [UniProt]

UniProt: O60566