Cadherin 5 antibody

Catalog No. ABIN7880132

This Goat Polyclonal antibody specifically detects Cadherin 5 in ELISA, FACS and IF. It exhibits reactivity toward Human.

Quick Overview for Cadherin 5 antibody (ABIN7880132)

Target: Cadherin 5 (CDH5)

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This Cadherin 5 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-Cadherin 5 Antibody

Purpose: Cadherin 5 Antibody / VE Cadherin

Sequence: KQARAHGKSV PE

Purification: Antigen affinity

Immunogen: Amino acids KQARAHGKSVPE were used as the immunogen for this Cadherin 5 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Cadherin 5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X TBS, pH 7.3, with 0.5 % BSA (US sourced) and 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and store the Cadherin 5 antibody at -20oC.

Target Details for Cadherin 5

Target: Cadherin 5 (CDH5)

Alternative Name: Cadherin 5

Background: Cadherin 5 is primarily expressed in endothelial cells, where it plays a critical role in regulating cell-cell adhesion and maintaining the integrity of the vascular barrier. Through its interactions with other Cadherin molecules and cytoskeletal components, Cadherin 5 helps to form adherens junctions, specialized structures that hold adjacent cells together and facilitate cell communication. Research has shown that mutations or dysregulation of Cadherin 5 can lead to various pathologies, including vascular dysfunction, increased permeability of blood vessels, and impaired wound healing. In addition, Cadherin 5 has been implicated in the progression of cancer, as aberrant expression of this molecule can promote tumor invasion and metastasis.

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2