CPS1 antibody

Catalog No. ABIN7880153

This Mouse Monoclonal antibody specifically detects CPS1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for CPS1 antibody (ABIN7880153)

Target: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CPS1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CPS1-9865

Product Details anti-CPS1 Antibody

Purpose: Carbamoyl phosphate synthetase 1 Antibody / CPS1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein from human Carbamoyl phosphate synthetase 1 protein was used as the immunogen for the Carbamoyl phosphate synthetase 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Carbamoyl phosphate synthetase 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Carbamoyl phosphate synthetase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CPS1

Target: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Alternative Name: Carbamoyl phosphate synthetase 1

Background: This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process