CPS1 antibody

Catalog No. ABIN7880156

This Mouse Monoclonal antibody specifically detects CPS1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for CPS1 antibody (ABIN7880156)

Target: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CPS1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CPS1-8420

Product Details anti-CPS1 Antibody

Purpose: CPS1 Antibody / Carbamoyl phosphate synthetase 1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant human CPS1 protein was used as the immunogen for the CPS1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CPS1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the CPS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CPS1

Target: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Alternative Name: CPS1

Background: This mAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process