Cathepsin B antibody

Catalog No. ABIN7880201

This Rabbit Monoclonal antibody specifically detects Cathepsin B in WB. It exhibits reactivity toward Human.

Quick Overview for Cathepsin B antibody (ABIN7880201)

Target: Cathepsin B (CTSB)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Cathepsin B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: AAFO-3

Product Details anti-Cathepsin B Antibody

Purpose: CTSB Antibody / Cathepsin B

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Cathepsin B / CTSB was used as the immunogen for the CTSB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CTSB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the CTSB antibody at -20oC.

Target Details for Cathepsin B

Target: Cathepsin B (CTSB)

Alternative Name: CTSB

Background: The CTSB gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. [RefSeq]

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades