Cathepsin L antibody

Catalog No. ABIN7880208

The Rabbit Polyclonal anti-Cathepsin L antibody is suitable to detect Cathepsin L in samples from Mouse and Rat. It has been validated for WB, IHC (p) and FACS.

Quick Overview for Cathepsin L antibody (ABIN7880208)

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin L antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-Cathepsin L Antibody

Purpose: Cathepsin L Antibody / Ctsl

Sequence: KYRAEFAVAN DTGFVDIPQQ

Purification: Antigen affinity purified

Immunogen: Amino acids KYRAEFAVANDTGFVDIPQQ from the mouse protein were used as the immunogen for the Cathepsin L antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cathepsin L antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Cathepsin L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Cathepsin L

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Alternative Name: Cathepsin L

Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.

UniProt: P06797

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades