Cathepsin L antibody

Catalog No. ABIN7880209

The Rabbit Polyclonal anti-Cathepsin L antibody (ABIN7880209) specifically detects Cathepsin L in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for Cathepsin L antibody (ABIN7880209)

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin L antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Cathepsin L Antibody

Purpose: CTSL Antibody / Cathepsin L

Sequence: EATEESCKYN PKYSVAND

Purification: Antigen affinity purified

Immunogen: Amino acids EATEESCKYNPKYSVAND from the human protein were used as the immunogen for the CTSL antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CTSL antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CTSL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Cathepsin L

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Alternative Name: CTSL

Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.

UniProt: P07711

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades