CENPB antibody

Catalog No. ABIN7880385

The Rabbit Polyclonal anti-CENPB antibody is suitable to detect CENPB in samples from Human. It has been validated for WB, IF and FACS.

Quick Overview for CENPB antibody (ABIN7880385)

Target: CENPB (Centromere Protein B (CENPB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPB antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-CENPB Antibody

Purpose: CENPB Antibody / Centromere protein B

Sequence: HLEHDLVHVT RKNHA

Purification: Antigen affinity purified

Immunogen: Amino acids HLEHDLVHVTRKNHA from the human protein were used as the immunogen for the CENPB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CENPB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CENPB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CENPB

Target: CENPB (Centromere Protein B (CENPB))

Alternative Name: CENPB

Background: Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

UniProt: P07199