Recombinant Ceruloplasmin antibody

Catalog No. ABIN7880387

This Rabbit Monoclonal antibody specifically detects Ceruloplasmin in WB. It exhibits reactivity toward Human and Rat.

Quick Overview for Recombinant Ceruloplasmin antibody (ABIN7880387)

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Ceruloplasmin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 31C62

Product Details anti-Ceruloplasmin Antibody

Purpose: Ceruloplasmin Antibody / CP

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Ceruloplasmin was used as the immunogen for the Ceruloplasmin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Ceruloplasmin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Ceruloplasmin antibody at -20oC.

Target Details for Ceruloplasmin

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Alternative Name: Ceruloplasmin

Background: Ceruloplasmin antibody detects ceruloplasmin, a copper binding glycoprotein encoded by the CP gene. Ceruloplasmin is synthesized in the liver and secreted into the plasma, where it carries more than 95 percent of circulating copper. It functions as a ferroxidase enzyme that oxidizes Fe2 plus to Fe3 plus, enabling iron binding to transferrin. Through this activity, ceruloplasmin maintains systemic iron and copper balance, supports antioxidant defense, and regulates oxidative stress.

Ceruloplasmin antibody is widely applied in studies of metabolism, neurodegeneration, and inflammatory disease. Abnormal ceruloplasmin levels are associated with Wilson disease, aceruloplasminemia, and other disorders of copper metabolism. In addition, altered expression occurs in Parkinson disease and Alzheimer disease, where oxidative stress contributes to pathogenesis. By detecting ceruloplasmin, researchers can evaluate copper homeostasis and its links to neurological disorders.

In western blot assays, ceruloplasmin antibody detects protein bands of the expected size in serum and liver extracts. Immunohistochemistry highlights hepatocyte production and distribution in tissues, while ELISA applications support quantification of ceruloplasmin levels in plasma. These methods make ceruloplasmin antibody useful for both clinical and experimental research.

Ceruloplasmin also acts as an acute phase reactant, with levels rising during inflammation and infection. Elevated ceruloplasmin is observed in autoimmune disease, cardiovascular disease, and cancer. By applying ceruloplasmin antibody, scientists can study how changes in CP expression reflect inflammation and metabolic stress.

Ceruloplasmin antibody from NSJ Bioreagents offers reliable specificity for studying copper and iron metabolism, oxidative stress, and disease mechanisms. Its performance across multiple assays makes it a valuable resource for metabolic and neurological research.

UniProt: P00450

Pathways: Transition Metal Ion Homeostasis