Recombinant CRCP antibody

Catalog No. ABIN7880389

The Rabbit Monoclonal anti-CRCP antibody (Clone 30C57) (ABIN7880389) specifically detects CRCP in WB, IHC, IF, IP and ICC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant CRCP antibody (ABIN7880389)

Target: CRCP (CGRP Receptor Component (CRCP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CRCP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: 30C57

Product Details anti-CRCP Antibody

Purpose: CRCP Antibody / CGRP receptor component protein

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human CRCP was used as the immunogen for the CRCP antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CRCP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the CRCP antibody at -20oC.

Target Details for CRCP

Target: CRCP (CGRP Receptor Component (CRCP))

Alternative Name: CRCP

Background: CRCP antibody detects CGRP receptor component protein, encoded by the CRCP gene. This protein is a cytosolic and membrane associated component that is essential for functional signaling of calcitonin gene related peptide (CGRP) receptors. CRCP interacts with calcitonin receptor like receptor and receptor activity modifying proteins to stabilize receptor complexes and couple them to intracellular signaling. CRCP antibody provides researchers with a critical tool for investigating neuropeptide signaling, vascular regulation, and pain pathways.

CGRP is a neuropeptide involved in vasodilation, pain transmission, and neurogenic inflammation. Functional CGRP receptors require three components: calcitonin receptor like receptor, a receptor activity modifying protein, and CRCP. Research using CRCP antibody has shown that CRCP is required for coupling receptor activation to downstream signaling through G proteins and adenylyl cyclase. Without CRCP, receptor complexes fail to properly signal, underscoring its essential role as a scaffolding factor in peptide receptor function.

CRCP has been extensively studied in the context of migraine. CGRP is a well established mediator of migraine attacks, and antagonists of CGRP receptors have been developed as effective migraine therapies. Studies with CRCP antibody have confirmed that CRCP expression levels influence receptor signaling efficiency, making it an important determinant of migraine susceptibility and treatment response. Because CGRP signaling also regulates vascular tone, CRCP plays a role in cardiovascular homeostasis as well.

Beyond migraine, CRCP contributes to nociception, inflammation, and central nervous system function. Research with CRCP antibody has demonstrated that reduced expression impairs neuronal responses to CGRP, while overexpression amplifies vasodilatory and inflammatory signaling. Its expression in vascular smooth muscle and neuronal tissue highlights its dual roles in vascular biology and sensory processing. Dysregulation of CRCP may therefore contribute to both neurological and cardiovascular disease.

CRCP antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting confirms expression in neuronal and vascular tissues, immunohistochemistry highlights its distribution in smooth muscle and brain, and immunofluorescence demonstrates colocalization with receptor partners. These approaches make CRCP antibody a versatile tool for examining receptor assembly, neuropeptide signaling, and disease mechanisms.

By supplying validated CRCP antibody reagents, NSJ Bioreagents supports research into neuropeptide biology, migraine, and vascular regulation. Detection of CGRP receptor component protein allows researchers to explore how receptor assembly and signaling influence health and disease.

UniProt: O75575