Recombinant CXCR6 antibody

Catalog No. ABIN7880402

This Rabbit Monoclonal antibody specifically detects CXCR6 in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant CXCR6 antibody (ABIN7880402)

Target: CXCR6 (Chemokine (C-X-C Motif) Receptor 6 (CXCR6))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CXCR6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 31C52

Product Details anti-CXCR6 Antibody

Purpose: CXCR6 Antibody / C-X-C chemokine receptor type 6 / CD186

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CXCR6 / CD186 was used as the immunogen for the CXCR6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CXCR6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the CXCR6 antibody at -20oC.

Target Details for CXCR6

Target: CXCR6 (Chemokine (C-X-C Motif) Receptor 6 (CXCR6))

Alternative Name: CXCR6

Background: CXCR6 antibody detects C-X-C chemokine receptor type 6, a G protein coupled receptor encoded by the CXCR6 gene. CXCR6 binds the chemokine ligand CXCL16, mediating chemotaxis and adhesion of T cells, natural killer T cells, and other immune populations. It is highly expressed in liver, lung, and inflamed tissues, where it regulates immune surveillance, inflammation, and host-pathogen interactions.

CXCR6 antibody is widely applied in immunology, oncology, and infectious disease research. In immunity, CXCR6 guides tissue resident memory T cells and NKT cells to inflamed sites, supporting pathogen defense and tissue homeostasis. In cancer, CXCR6 expression is associated with tumor infiltrating lymphocytes and modulation of the tumor microenvironment. By detecting CXCR6, researchers can study how chemokine receptors regulate immunity and disease progression.

Flow cytometry distinguishes CXCR6 positive lymphocyte subsets in blood and tissues. Immunohistochemistry maps expression in liver, lung, and tumors, while immunofluorescence highlights surface localization on immune cells. These applications provide versatile tools for studying chemokine receptor biology.

CXCR6 also plays roles in viral infection and chronic inflammation. It serves as a co-receptor for HIV entry into cells and contributes to pathogenesis of liver disease. By applying CXCR6 antibody, scientists can investigate receptor function in immune surveillance, infection, and cancer immunity.

CXCR6 antibody from NSJ Bioreagents provides strong specificity for detecting this chemokine receptor across research platforms. Its proven reliability ensures accurate detection in immunology and translational studies.

UniProt: O00574