CHI3L2 antibody

Catalog No. ABIN7880406

The Mouse Monoclonal anti-CHI3L2 antibody is suitable to detect CHI3L2 in samples from Human. It has been validated for ELISA.

Quick Overview for CHI3L2 antibody (ABIN7880406)

Target: CHI3L2 (Chitinase 3-Like 2 (CHI3L2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CHI3L2 antibody is un-conjugated

Application: ELISA

Clone: 1B2-G4

Product Details anti-CHI3L2 Antibody

Purpose: CHI3L2 Antibody / Chitinase 3 like 2 / YKL-39

Purification: Protein G affinity

Immunogen: A recombinant YKL-39 partial protein was used as the immunogen for the CHI3L2 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the CHI3L2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CHI3L2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CHI3L2

Target: CHI3L2 (Chitinase 3-Like 2 (CHI3L2))

Alternative Name: CHI3L2

Background: The CHI3L2 protein, also known as chitinase-3-like protein 2, is a glycoprotein that belongs to the chitinase protein family. It is primarily associated with various biological processes, including inflammation, tissue remodeling, and immune responses. CHI3L2 is expressed in various tissues, such as the lungs, liver, and immune cells, suggesting its involvement in diverse physiological functions. CHI3L2 has been implicated in modulating immune responses and inflammatory processes. It is often associated with conditions characterized by inflammation, such as autoimmune diseases and certain cancers. The protein's precise mechanism of action is still under investigation, but it is believed to play a role in cell signaling and the regulation of cellular interactions within the immune system. HI3L2/YKL-39 has been explored as a biomarker in cancer diagnosis: Elevated levels of CHI3L2 in the serum or tissues have been investigated as potential biomarkers for cancer detection and prognosis. Monitoring CHI3L2 levels may aid in cancer diagnosis and assessment of disease progression. Inflammatory joint diseases, such as rheumatoid arthritis, have shown increased CHI3L2 expression. Detection of CHI3L2 levels in synovial fluid or blood may have diagnostic value in rheumatoid arthritis. CHI3L2/YKl-39 has also been explored as a biomarker for cardiovascular diseases. Elevated levels in the blood may indicate vascular inflammation and provide insights into cardiovascular risk.

UniProt: Q15782