Recombinant CLIC4 antibody

Catalog No. ABIN7880409

The Rabbit Monoclonal anti-CLIC4 antibody is suitable to detect CLIC4 in samples from Human, Mouse and Rat. It has been validated for WB, IHC, ICC, IF, IP and FACS.

Quick Overview for Recombinant CLIC4 antibody (ABIN7880409)

Target: CLIC4 (Chloride Intracellular Channel 4 (CLIC4))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CLIC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS)

Clone: 30C24

Product Details anti-CLIC4 Antibody

Purpose: CLIC4 Antibody / Chloride intracellular channel protein 4

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CLIC4 was used as the immunogen for the CLIC4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CLIC4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the CLIC4 antibody at -20oC.

Target Details for CLIC4

Target: CLIC4 (Chloride Intracellular Channel 4 (CLIC4))

Alternative Name: CLIC4

Background: CLIC4 antibody targets chloride intracellular channel protein 4, a member of the CLIC family of proteins that function as intracellular chloride channels and signaling modulators. Unlike classical ion channels, CLIC4 can exist in both soluble and membrane-associated forms, transitioning between states to regulate chloride conductance. This protein is expressed across many tissues, including endothelial cells, immune cells, and epithelial cells, where it contributes to processes such as apoptosis, angiogenesis, and cellular stress responses.

Research using CLIC4 antibody has demonstrated its involvement in multiple pathological processes. CLIC4 is frequently upregulated during tissue remodeling and fibrotic diseases, where it influences transforming growth factor-beta (TGF-beta) signaling pathways. It has also been studied in the context of cancer, with evidence suggesting that CLIC4 contributes to tumor progression and metastasis through regulation of cell migration and invasion. In immune biology, CLIC4 has been implicated in the modulation of macrophage activation and inflammatory responses.

Validated clones for CLIC4 detection perform well in assays including western blot, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to monitor subcellular localization, expression changes under stress conditions, and signaling outcomes tied to chloride channel activity. The versatility of CLIC4 in both membrane transport and cell signaling makes it a protein of interest in diverse fields of study.

NSJ Bioreagents offers this CLIC4 antibody to support investigations in cancer biology, fibrosis, and cellular signaling. Alternate names include chloride intracellular channel protein 4 antibody, CLIC4A antibody, MSTP046 antibody, HuH1 antibody, and DKFZp564F012 antibody.

UniProt: Q9Y696