Claudin 1 antibody

Catalog No. ABIN7880442

The Rabbit Polyclonal anti-Claudin 1 antibody is suitable to detect Claudin 1 in samples from Human. It has been validated for IF and IHC (p).

Quick Overview for Claudin 1 antibody (ABIN7880442)

Target: Claudin 1 (CLDN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 1 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Claudin 1 Antibody

Purpose: Claudin 1 Antibody / CLDN1

Sequence: ATAWYGNRIV QEFYD

Purification: Affinity purified

Immunogen: Amino acids ATAWYGNRIVQEFYD from the human protein were used as the immunogen for the Claudin 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Claudin 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Claudin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Claudin 1

Target: Claudin 1 (CLDN1)

Alternative Name: Claudin 1

Background: Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

UniProt: O95832

Pathways: Cell-Cell Junction Organization, Hepatitis C