Claudin 16 antibody

Catalog No. ABIN7880445

The Rabbit Polyclonal anti-Claudin 16 antibody is suitable to detect Claudin 16 in samples from Human, Mouse and Rat. It has been validated for WB, FACS and IF.

Quick Overview for Claudin 16 antibody (ABIN7880445)

Target: Claudin 16 (CLDN16)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 16 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-Claudin 16 Antibody

Purpose: Claudin 16 Antibody / CLDN16

Sequence: KSYSAPRTET AKMYAVDTRV

Purification: Affinity purified

Immunogen: Amino acids KSYSAPRTETAKMYAVDTRV from the human protein were used as the immunogen for the Claudin 16 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Claudin 16 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Claudin 16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Claudin 16

Target: Claudin 16 (CLDN16)

Alternative Name: Claudin 16

Background: Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.

UniProt: Q9Y5I7

Pathways: Hepatitis C