Claudin 3 antibody

Catalog No. ABIN7880446

The Rabbit Polyclonal anti-Claudin 3 antibody (ABIN7880446) specifically detects Claudin 3 in WB and IF. The antibody is reactive with Mouse and Rat samples.

Quick Overview for Claudin 3 antibody (ABIN7880446)

Target: Claudin 3 (CLDN3)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Claudin 3 Antibody

Purpose: Claudin 3 Antibody / CLDN3

Sequence: RDKYAPTKIL YSAPRST

Purification: Affinity purified

Immunogen: Amino acids RDKYAPTKILYSAPRST from the mouse protein were used as the immunogen for the Claudin 3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Claudin 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Claudin 3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Claudin 3

Target: Claudin 3 (CLDN3)

Alternative Name: Claudin 3

Background: Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology.

UniProt: Q9Z0G9

Pathways: Hepatitis C