Claudin 7 antibody

Catalog No. ABIN7880451

The Rabbit Polyclonal anti-Claudin 7 antibody is suitable to detect Claudin 7 in samples from Mouse. It has been validated for WB.

Quick Overview for Claudin 7 antibody (ABIN7880451)

Target: Claudin 7 (CLDN7)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Claudin 7 Antibody

Purpose: Cldn7 Antibody / Claudin 7

Sequence: SESKAAYRAP RSYPKSNSSK EYV

Purification: Affinity purified

Immunogen: Amino acids SESKAAYRAPRSYPKSNSSKEYV from the mouse protein were used as the immunogen for the Cldn7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cldn7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Cldn7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Claudin 7

Target: Claudin 7 (CLDN7)

Alternative Name: Cldn7

Background: Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene.

UniProt: Q9Z261

Pathways: Hepatitis C