Recombinant C1QA antibody

Catalog No. ABIN7880493

The Rabbit Monoclonal anti-C1QA antibody is suitable to detect C1QA in samples from Human and Rat. It has been validated for WB and IHC.

Quick Overview for Recombinant C1QA antibody (ABIN7880493)

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This C1QA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 31C57

Product Details anti-C1QA Antibody

Purpose: C1QA Antibody / Complement component 1 subcomponent subunit A

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human C1QA was used as the immunogen for the C1QA antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the C1QA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the C1QA antibody at -20oC.

Target Details for C1QA

Target: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Alternative Name: C1QA

Background: C1QA antibody detects complement component 1 subcomponent subunit A, encoded by the C1QA gene. C1QA is one of three chains (A, B, and C) that assemble to form the C1q protein complex, a recognition unit of the classical complement pathway. C1q binds to antibodies or immune complexes, initiating complement activation and promoting clearance of pathogens and apoptotic cells. Through these roles, C1QA is central to innate immunity and host defense.

C1QA antibody is commonly used in immunology, inflammation, and autoimmune disease research. C1QA expression is highest in monocytes, macrophages, and dendritic cells. It functions as a pattern recognition receptor that bridges innate and adaptive immunity. By detecting C1QA, researchers can study activation of complement pathways and regulation of immune responses.

In western blot assays, C1QA antibody detects protein bands of expected size in immune cell extracts. Immunohistochemistry highlights strong expression in macrophages and tissue resident immune cells. Immunofluorescence enables visualization of C1QA in immune synapses and complement activation sites. ELISA supports quantification of circulating C1QA in biological samples.

Deficiency of C1QA is associated with autoimmune disorders such as systemic lupus erythematosus, underscoring its importance in self tolerance and immune clearance. Elevated expression of C1QA has been linked to chronic inflammation and neurodegenerative diseases, including Alzheimer disease, where complement activation contributes to pathology. By applying C1QA antibody, scientists can investigate how alterations in complement regulation affect health and disease.

C1QA antibody from NSJ Bioreagents offers reliable specificity for complement research. Its performance across methods ensures accurate detection of this key immune recognition protein.

UniProt: P02745

Pathways: Complement System