CUBN antibody

Catalog No. ABIN7880521

The Rabbit Monoclonal anti-CUBN antibody (Clone EF-3) (ABIN7880521) specifically detects CUBN in WB. The antibody is reactive with Human samples.

Quick Overview for CUBN antibody (ABIN7880521)

Target: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CUBN antibody is un-conjugated

Application: Western Blotting (WB)

Clone: EF-3

Product Details anti-CUBN Antibody

Purpose: Cubilin Antibody / CUBN

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Cubilin / CUBN was used as the immunogen for the Cubilin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cubilin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Cubilin antibody at -20oC.

Target Details for CUBN

Target: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Alternative Name: Cubilin

Background: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. [UniProt]

UniProt: O60494

Pathways: Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism