Recombinant DCAF13 antibody

Catalog No. ABIN7880606

This Rabbit Monoclonal antibody specifically detects DCAF13 in WB, IHC and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant DCAF13 antibody (ABIN7880606)

Target: DCAF13 (DDB1 and CUL4 Associated Factor 13 (DCAF13))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This DCAF13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 32D85

Product Details anti-DCAF13 Antibody

Purpose: DCAF13 Antibody / DDB1- and CUL4-associated factor 13

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human DCAF13 was used as the immunogen for the DCAF13 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DCAF13 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the DCAF13 antibody at -20oC.

Target Details for DCAF13

Target: DCAF13 (DDB1 and CUL4 Associated Factor 13 (DCAF13))

Alternative Name: DCAF13

Background: DCAF13 antibody detects DDB1- and CUL4-associated factor 13, encoded by the DCAF13 gene. DDB1- and CUL4-associated factor 13 is a substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex, directing ubiquitination and degradation of specific proteins. DCAF13 antibody provides researchers with a key reagent to study ubiquitin-mediated proteolysis, cell cycle regulation, and cancer biology.

DDB1- and CUL4-associated factor 13 belongs to the family of WD repeat proteins that serve as adaptors for CUL4-based E3 ligases. Research using DCAF13 antibody has shown that it recognizes substrates and recruits them to the ligase complex, ensuring precise turnover of proteins that regulate transcription and cell cycle progression. This function is critical for maintaining protein homeostasis and genomic stability.

Studies with DCAF13 antibody have revealed that it plays roles in embryonic development and tumorigenesis. In embryonic cells, DCAF13 supports proliferation by targeting key regulators of transcription and signaling for degradation. In cancers, overexpression of DCAF13 enhances tumor growth and survival by destabilizing tumor suppressor proteins. These observations highlight the importance of DDB1- and CUL4-associated factor 13 in growth control and oncogenesis.

DCAF13 has also been implicated in stress responses. Research using DCAF13 antibody has demonstrated that the protein participates in DNA damage repair pathways, regulating protein stability during genotoxic stress. By coordinating protein turnover with DNA repair, DCAF13 contributes to genome integrity.

DCAF13 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous protein levels, immunohistochemistry reveals expression in proliferative tissues, and immunofluorescence highlights nuclear localization consistent with transcriptional regulation. These approaches make DCAF13 antibody valuable for investigating ubiquitin signaling and cancer biology.

By supplying validated DCAF13 antibody reagents, NSJ Bioreagents supports research into protein degradation, cell cycle regulation, and oncogenesis. Detection of DDB1- and CUL4-associated factor 13 provides insights into how E3 ligase adaptors regulate cellular function and disease.

UniProt: Q9NV06