Recombinant Desmocollin 1 antibody

Catalog No. ABIN7880619

The Rabbit Monoclonal anti-Desmocollin 1 antibody is suitable to detect Desmocollin 1 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for Recombinant Desmocollin 1 antibody (ABIN7880619)

Target: Desmocollin 1 (DSC1)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Desmocollin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 31D56

Product Details anti-Desmocollin 1 Antibody

Purpose: DSC1 Antibody / Desmocollin 1

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human Desmocollin 1 was used as the immunogen for the DSC1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DSC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the DSC1 antibody at -20oC.

Target Details for Desmocollin 1

Target: Desmocollin 1 (DSC1)

Alternative Name: DSC1

Background: DSC1 antibody detects Desmocollin 1, encoded by the DSC1 gene. Desmocollin 1 is a calcium-dependent glycoprotein and a member of the cadherin superfamily that forms part of desmosomes, specialized structures mediating cell-cell adhesion in epithelial tissues. DSC1 antibody provides researchers with an important reagent for studying adhesion, epidermal integrity, and disease processes involving skin and epithelial biology.

Desmocollin 1 is a transmembrane protein that interacts with desmogleins, plakoglobin, and desmoplakin to form stable desmosomal junctions. Research using DSC1 antibody has shown that it is expressed predominantly in stratified squamous epithelia, where it contributes to strong intercellular adhesion. This adhesion maintains tissue integrity under mechanical stress, particularly in the skin and mucosal surfaces.

Studies with DSC1 antibody have revealed that Desmocollin 1 exists in multiple isoforms generated by alternative splicing. These isoforms contribute to structural diversity within desmosomes and enable fine-tuning of adhesive strength. Regulation of isoform expression is developmentally controlled and varies between epithelial layers, suggesting specialized functions for different Desmocollin 1 variants.

Dysregulation of Desmocollin 1 is linked to disease. Research using DSC1 antibody has demonstrated that mutations in DSC1 cause striate palmoplantar keratoderma, a skin disorder characterized by thickening of the palms and soles. Autoantibodies against Desmocollin 1 are found in autoimmune skin diseases such as pemphigus. Loss of Desmocollin 1 expression has also been reported in cancers, where reduced adhesion facilitates invasion and metastasis. These findings highlight the importance of DSC1 in health and disease.

Desmocollin 1 also contributes to barrier function. Studies with DSC1 antibody have shown that intact desmosomal adhesion prevents pathogen invasion and regulates paracellular permeability. This function underscores the role of Desmocollin 1 not only in mechanical integrity but also in defense and tissue homeostasis.

DSC1 antibody is commonly applied in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry highlights localization in epithelial layers, immunofluorescence reveals colocalization with other desmosomal proteins at junctions, and western blotting detects isoform expression. These applications make DSC1 antibody essential for adhesion biology and pathology research.

By providing validated DSC1 antibody reagents, NSJ Bioreagents supports studies into epithelial adhesion, skin disease, and cancer. Detection of Desmocollin 1 provides insight into how desmosomal proteins maintain tissue structure and how their disruption leads to disease.

UniProt: Q08554