Desmoglein 1 antibody

Catalog No. ABIN7880620

The Mouse Monoclonal anti-Desmoglein 1 antibody (Clone 32-2B) (ABIN7880620) specifically detects Desmoglein 1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Desmoglein 1 antibody (ABIN7880620)

Target: Desmoglein 1 (DSG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: 32-2B

Product Details anti-Desmoglein 1 Antibody

Purpose: Desmoglein 1 Antibody / DSG1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Bovine desmoglein (desmosomal glyco protein I) from nasal epidermis was used as the immunogen for the Desmoglein 1 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Desmoglein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Desmoglein 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: Desmoglein 1

Background: Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

UniProt: Q02413

Pathways: Cell-Cell Junction Organization