Recombinant Desmoglein 1 antibody

Catalog No. ABIN7880622

The Rabbit Monoclonal anti-Desmoglein 1 antibody is suitable to detect Desmoglein 1 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant Desmoglein 1 antibody (ABIN7880622)

Target: Desmoglein 1 (DSG1)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: DSG1-8576R

Product Details anti-Desmoglein 1 Antibody

Purpose: Desmoglein 1 Antibody / DSG1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant human DSG1 protein was used as the immunogen for the Desmoglein 1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Desmoglein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Desmoglein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: Desmoglein 1

Background: Recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

UniProt: Q02413

Pathways: Cell-Cell Junction Organization