ELP3/KAT9 antibody

Catalog No. ABIN7880676

The Mouse Monoclonal anti-ELP3/KAT9 antibody is suitable to detect ELP3/KAT9 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for ELP3/KAT9 antibody (ABIN7880676)

Target: ELP3/KAT9 (ELP3) (Elongator complex protein 3 (ELP3))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ELP3/KAT9 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 8B4

Product Details anti-ELP3/KAT9 Antibody

Purpose: Elongator complex protein 3 Antibody / ELP3 / KAT9

Sequence: RDPTKFQHQG FGMLLMEEAE RIAREEH

Purification: Antigen affinity purified

Immunogen: Amino acids RDPTKFQHQGFGMLLMEEAERIAREEH were used as the immunogen for the Elongator complex protein 3 antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the Elongator complex protein 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Elongator complex protein 3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ELP3/KAT9

Target: ELP3/KAT9 (ELP3) (Elongator complex protein 3 (ELP3))

Alternative Name: Elongator complex protein 3

Background: Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene. It is mapped to 8p21.1. ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex. In mammals, ELP3 is important for paternal DNA demethylationafterfertilization.ELP3 is potentially involved in cellular redox homeostasis by mediating the acetylation ofglucose-6-phosphate dehydrogenase. Besides, ELP3 may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

UniProt: Q9H9T3