Recombinant EMC4 antibody

Catalog No. ABIN7880733

The Rabbit Monoclonal anti-EMC4 antibody is suitable to detect EMC4 in samples from Human, Mouse and Rat. It has been validated for WB, IHC and IP.

Quick Overview for Recombinant EMC4 antibody (ABIN7880733)

Target: EMC4 (ER Membrane Protein Complex Subunit 4 (EMC4))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This EMC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 30E32

Product Details anti-EMC4 Antibody

Purpose: EMC4 Antibody / ER membrane protein complex subunit 4

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human EMC4 was used as the immunogen for the EMC4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the EMC4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the EMC4 antibody at -20oC.

Target Details for EMC4

Target: EMC4 (ER Membrane Protein Complex Subunit 4 (EMC4))

Alternative Name: EMC4

Background: EMC4 antibody recognizes ER membrane protein complex subunit 4, a component of the endoplasmic reticulum membrane complex (EMC). The EMC facilitates insertion of transmembrane proteins into the ER and aids in proper folding of multipass proteins. EMC4 plays a role in maintaining ER homeostasis and ensuring the quality control of membrane protein biosynthesis.

Research with EMC4 antibody has shown that loss of EMC function leads to defective protein targeting, ER stress, and activation of the unfolded protein response. EMC4 has also been linked to viral infection processes, where certain viruses hijack EMC components to ensure proper expression of their envelope proteins. These findings highlight EMC4's importance in both normal physiology and infectious disease biology.

Antibodies against EMC4 are validated in assays such as western blot, immunohistochemistry, and immunofluorescence. These reagents provide reliable detection of EMC4, allowing researchers to investigate ER protein insertion pathways and responses to cellular stress.

NSJ Bioreagents provides this EMC4 antibody for research on ER biology, membrane protein folding, and host-pathogen interactions. Alternate names include ER membrane protein complex subunit 4 antibody, EMC4A antibody, and transmembrane protein 93 antibody.

UniProt: Q5J8M3