Recombinant FAM50A antibody

Catalog No. ABIN7880762

This Rabbit Monoclonal antibody specifically detects FAM50A in WB, IHC, IF and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant FAM50A antibody (ABIN7880762)

Target: FAM50A (Family with Sequence Similarity 50, Member A (FAM50A))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FAM50A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 30F36

Product Details anti-FAM50A Antibody

Purpose: FAM50A Antibody / Family with sequence similarity 50 member A

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human FAM50A was used as the immunogen for the FAM50A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FAM50A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the FAM50A antibody at -20oC.

Target Details for FAM50A

Target: FAM50A (Family with Sequence Similarity 50, Member A (FAM50A))

Alternative Name: FAM50A

Background: FAM50A antibody detects family with sequence similarity 50 member A, a nuclear protein involved in RNA processing and gene expression regulation. FAM50A is ubiquitously expressed and localized primarily to the nucleoplasm, where it associates with spliceosomal components and contributes to pre-mRNA splicing. Though relatively understudied compared to other RNA-binding proteins, evidence suggests FAM50A plays an important role in transcriptional control and cellular homeostasis.

Research using FAM50A antibody has linked the protein to development and disease. Genetic studies reveal that mutations in FAM50A cause Armfield X-linked intellectual disability syndrome, characterized by developmental delay, dysmorphic features, and neurobehavioral abnormalities. The disorder underscores FAM50A's significance in neurodevelopment and proper RNA processing. Knockout models further demonstrate embryonic lethality or severe neurological phenotypes, confirming its essential role.

Beyond development, FAM50A has been implicated in cancer biology. Altered expression is observed in several tumor types, where it may influence splicing decisions and transcriptional programs that favor proliferation. Transcriptome studies suggest that dysregulation of FAM50A perturbs global RNA processing networks, contributing to oncogenic transformation.

At the molecular level, FAM50A interacts with spliceosome-associated proteins, ribonucleoprotein complexes, and chromatin regulators. These interactions suggest a broader role in coupling transcription to RNA maturation. Additional evidence connects FAM50A to cell cycle control, where depletion disrupts proliferation and induces apoptosis.

Antibodies against FAM50A are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents enable detection of FAM50A in tissue and cell culture, supporting research into RNA biology, neurodevelopment, and tumorigenesis. Clone-based antibodies ensure reproducibility and specificity across experimental conditions.

NSJ Bioreagents offers this FAM50A antibody for research into RNA processing, gene regulation, and disease.

UniProt: Q14320