Recombinant GAS2 antibody

Catalog No. ABIN7880928

The Rabbit Monoclonal anti-GAS2 antibody is suitable to detect GAS2 in samples from Human. It has been validated for WB and IHC.

Quick Overview for Recombinant GAS2 antibody (ABIN7880928)

Target: GAS2 (Growth Arrest-Specific 2 (GAS2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GAS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 31G23

Product Details anti-GAS2 Antibody

Purpose: GAS2 Antibody / Growth arrest specific protein 2

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human GAS2 was used as the immunogen for the GAS2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GAS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the GAS2 antibody at -20oC.

Target Details for GAS2

Target: GAS2 (Growth Arrest-Specific 2 (GAS2))

Alternative Name: GAS2

Background: GAS2 antibody detects Growth arrest specific protein 2, encoded by the GAS2 gene. Growth arrest specific protein 2 is a cytoskeletal regulator that stabilizes microfilaments and microtubules. It is expressed during cell cycle arrest and differentiation, linking cytoskeletal dynamics to growth regulation. GAS2 antibody provides researchers with a useful reagent for studying cell growth, apoptosis, and cancer biology.

Growth arrest specific protein 2 contains actin binding domains and microtubule binding motifs that allow it to crosslink cytoskeletal components. Research using GAS2 antibody has demonstrated that it stabilizes actin filaments and microtubules during cell cycle arrest, contributing to maintenance of cell shape and integrity. By coordinating cytoskeletal structures, GAS2 helps control cell migration, adhesion, and survival.

In addition to cytoskeletal regulation, GAS2 is involved in apoptosis. Studies with GAS2 antibody have shown that it is cleaved by caspases during programmed cell death, producing fragments that promote cytoskeletal disassembly. This links GAS2 function to apoptotic morphology, including cell shrinkage and membrane blebbing. Dysregulation of GAS2 expression or cleavage contributes to abnormal cell survival in disease.

GAS2 has been studied in cancer, where its expression influences cell proliferation and migration. Research with GAS2 antibody has indicated that altered levels promote tumor progression by disrupting cytoskeletal control. Conversely, in some contexts GAS2 expression suppresses tumorigenesis by stabilizing growth arrest. This duality highlights its complex roles depending on cellular environment.

GAS2 antibody is used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full length and cleaved forms, immunohistochemistry shows distribution in growth arrested tissues, and immunofluorescence reveals colocalization with actin and tubulin. These applications make GAS2 antibody valuable in studies of cell cycle, cytoskeletal dynamics, and apoptosis.

By providing validated GAS2 antibody reagents, NSJ Bioreagents supports research into growth regulation, apoptosis, and cancer. Detection of Growth arrest specific protein 2 provides insight into how cytoskeletal stability intersects with cell fate decisions.

UniProt: O43903

Pathways: Caspase Cascade in Apoptosis