GCHFR antibody

Catalog No. ABIN7880935

The Mouse Monoclonal anti-GCHFR antibody (Clone GCHFR-7732) (ABIN7880935) specifically detects GCHFR in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for GCHFR antibody (ABIN7880935)

Target: GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GCHFR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: GCHFR-7732

Product Details anti-GCHFR Antibody

Purpose: GCHFR Antibody / GFRP (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human GCHFR protein was used as the immunogen for the GCHFR antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the GCHFR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the GCHFR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GCHFR

Target: GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))

Alternative Name: GCHFR

Background: GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. Cross-linking experiments have shown that GFRP is usually expressed as a homodimer or pentamer.

UniProt: P30047